未分類
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本研究為本實驗室系統性探討健康成人之年齡依賴性免疫特徵，並建立具臨床應用價值之免疫細胞參考範圍。研究結合363名台灣健康成人之原始資料，以及大規模系統性回顧與統合分析，全面解析T細胞、B細胞、自然殺手細胞（NK）及單核球等免疫子群隨年齡變化之趨勢。研究發現，隨著年齡增長，CD8⁺ T細胞與B細胞呈現下降，而CD4/CD8比例與NK細胞則顯著上升，顯示免疫老化之典型特徵；此外，初始型T細胞減少與記憶型T細胞增加的轉變亦清楚呈現。進一步分析亦揭示性別對免疫組成具有重要影響。本研究所建立之年齡與性別分層免疫參考值，可作為臨床免疫監測與精準醫療的重要基礎，對於老化相關疾病之預防與管理具有關鍵意義。 Our study represents a key achievement of our laboratory, providing a comprehensive characterization of age-dependent immune profiles in… Read more.
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IgA 腎病變是一種典型的免疫複合體疾病。致病機制主要源於黏膜免疫系統失調（如腸道或呼吸道反覆感染），導致血中出現異常的半乳糖缺乏-IgA1（Galactose-deficient IgA1, Gd-IgA1），進而引發一連串連鎖反應造成免疫系統攻擊腎臟組織。已知除了不正常B細胞抗體產生，亦存在腸胃道與呼吸道黏膜免疫缺陷；IgAN 患者體內的 gamma-delta T 細胞亞群常呈現數量減少或分佈異常。這種黏膜免疫屏障的失常，被認為是誘發體內產生異常 IgA 的主因之一。 亞東醫院腎臟內科與台大醫院合作，團隊研究發現，IgAN 患者的血漿 C5a、factor Ba、Gd-IgA1 均顯著高於 FSGS 患者與健康對照。這表示 IgAN 中不僅有終端補體路徑活化，也有替代補體路徑活化。其中 factor… Read more.
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Alzheimer’s disease is a dreadful disease affecting millions of people worldwide. Our lab has been fascinated by identifying peripheral immunological… Read more.
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TPMIC (Taiwan Precision Medicine Initiative on Cognitive Impairment) was established from the EMCIT study, the earlier study co-funded by Yen-Ling… Read more.
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We are super-interested in defining what is the best way to characterize human immunity and immune health. By collecting data… Read more.
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Methods
- Weekly field observations along fixed routes.
- Short interviews using a consistent guide.
- Sensor readings checked at the start of each session.
- Cleaning decisions documented as a changelog.
- Processing: normalized timestamps; flagged gaps; spot-checked outliers.
- Limits: some missing intervals during battery replacement.
Data & Ethics
Data
Upon request, sensitive locations have been removed from the public files. License: CC BY 4.0 for shared materials.
Ethics
Consent protocols used where applicable.
Contact
fieldnoteslab@ucc.ie
Chiu Lab FEMH 