本研究為本實驗室系統性探討健康成人之年齡依賴性免疫特徵，並建立具臨床應用價值之免疫細胞參考範圍。研究結合363名台灣健康成人之原始資料，以及大規模系統性回顧與統合分析，全面解析T細胞、B細胞、自然殺手細胞（NK）及單核球等免疫子群隨年齡變化之趨勢。研究發現，隨著年齡增長，CD8⁺ T細胞與B細胞呈現下降，而CD4/CD8比例與NK細胞則顯著上升，顯示免疫老化之典型特徵；此外，初始型T細胞減少與記憶型T細胞增加的轉變亦清楚呈現。進一步分析亦揭示性別對免疫組成具有重要影響。本研究所建立之年齡與性別分層免疫參考值，可作為臨床免疫監測與精準醫療的重要基礎，對於老化相關疾病之預防與管理具有關鍵意義。
Our study represents a key achievement of our laboratory, providing a comprehensive characterization of age-dependent immune profiles in healthy adults and establishing clinically relevant reference ranges for immune cell subsets. By integrating original data from 363 healthy Taiwanese adults with a large-scale systematic review and meta-analysis, we delineated age-related changes across major immune populations, including T cells, B cells, natural killer (NK) cells, and monocytes. The findings demonstrate that aging is associated with a decline in CD8⁺ T cells and B cells, accompanied by an increase in the CD4/CD8 ratio and NK cells—hallmarks of immunosenescence. A pronounced shift from naïve to memory T cell subsets was also observed. In addition, sex-specific differences in immune composition were identified. The age- and sex-stratified reference ranges established in this study provide a robust foundation for clinical immune monitoring and precision medicine, with important implications for the prevention and management of aging-related diseases.
Chang ST, Chuang YF, Li AH, et al. Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis. Immunity & Ageing. 2024;21:75.
Chiu Lab FEMH 
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