Mission
We publish findings, method notes, and reusable assets to support research.
Based at Dublin Institute for Environmental Research (DIER) in Ireland, the research group focuses on how environmental change shapes daily life—and how communities respond in practice.
Current projects
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Jan·12·2026
Immune response against neuronal-antigen and its relationship with neurodegeneration
寫作
Dec·16·2025
Artificial intelligence-enabled characterization of aging phenotypes
Urban Heat
Oct·06·2025
Proteomics identification of autoimmune diseases affecting the kidneys
Methods
Meet the NOTESLAB®
We invite researchers, community organizations, and public agencies to collaborate. Contact us to use or share datasets and protocols or to discuss joint projects.
Acknowledgements
NOTESLAB® is supported by a mix of institutional and project-based funding. Partner and funder acknowledgements are listed on relevant project and resource pages.
We’re open to collaboration.
Latest Notes
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本研究為本實驗室系統性探討健康成人之年齡依賴性免疫特徵，並建立具臨床應用價值之免疫細胞參考範圍。研究結合363名台灣健康成人之原始資料，以及大規模系統性回顧與統合分析，全面解析T細胞、B細胞、自然殺手細胞（NK）及單核球等免疫子群隨年齡變化之趨勢。研究發現，隨著年齡增長，CD8⁺ T細胞與B細胞呈現下降，而CD4/CD8比例與NK細胞則顯著上升，顯示免疫老化之典型特徵；此外，初始型T細胞減少與記憶型T細胞增加的轉變亦清楚呈現。進一步分析亦揭示性別對免疫組成具有重要影響。本研究所建立之年齡與性別分層免疫參考值，可作為臨床免疫監測與精準醫療的重要基礎，對於老化相關疾病之預防與管理具有關鍵意義。 Our study represents a key achievement of our laboratory, providing a comprehensive characterization of age-dependent immune profiles in… Read more.
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IgA 腎病變是一種典型的免疫複合體疾病。致病機制主要源於黏膜免疫系統失調（如腸道或呼吸道反覆感染），導致血中出現異常的半乳糖缺乏-IgA1（Galactose-deficient IgA1, Gd-IgA1），進而引發一連串連鎖反應造成免疫系統攻擊腎臟組織。已知除了不正常B細胞抗體產生，亦存在腸胃道與呼吸道黏膜免疫缺陷；IgAN 患者體內的 gamma-delta T 細胞亞群常呈現數量減少或分佈異常。這種黏膜免疫屏障的失常，被認為是誘發體內產生異常 IgA 的主因之一。 亞東醫院腎臟內科與台大醫院合作，團隊研究發現，IgAN 患者的血漿 C5a、factor Ba、Gd-IgA1 均顯著高於 FSGS 患者與健康對照。這表示 IgAN 中不僅有終端補體路徑活化，也有替代補體路徑活化。其中 factor… Read more.
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Alzheimer’s disease is a dreadful disease affecting millions of people worldwide. Our lab has been fascinated by identifying peripheral immunological… Read more.
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Meet the people behind
Our studies
Dr. Samira Ortiz
Principal Investigator
Urban heat, Field methods, Open data
Ciarán Walsh
Research Assistant
Sensors, Data cleaning, Field logistics
Daniel Okeke
MSc Student
Environmental justice, Interviews, Mapping
Niamh O’Sullivan
PhD Researcher
Water access, Community research, GIS
Amina El-Khoury
Postdoctoral Fellow
Coastal change, Risk, Mixed methods
Visiting Collaborators
Network
Partnerships, Coauthorship, Shared datasets
Funding & Partners
NotesLab® is supported by:
In collaboration with:
F.A.Q.
What’s the difference between Field Notes and Publications?
Field Notes are working-facing posts—method notes, reflections, and updates written for readability and practical reuse. Publications are formal research outputs (journal articles, reports, and working papers) with citation details and official links.
Can I reuse your datasets, protocols, or templates?
Often, yes. Each resource lists its license and any access conditions. If a dataset is restricted (e.g., sensitive locations or participant privacy), we’ll note how to request access.
How should I cite something from this site?
Use the citation information on the relevant page when available (publication citation, dataset version, or post date).
When in doubt, cite the page title, NotesLab®, the year, and the URL.
How do I collaborate or request access to restricted materials?
Email noteslab@dier.ie with a short description of your project and what you need (e.g., dataset version, intended use, timeline). We typically respond within 3–5 working days.
Chiu Lab FEMH 